Role of intravitreal bevacizumab in management of Eale’s Disease | Mehboob | Pakistan Journal of Medical Sciences Old Website

Role of intravitreal bevacizumab in management of Eale’s Disease

Mohammad Asim Mehboob, Muhammad Tahir, Huma Batool


Objective: To investigate the role of Intravitreal Bevacizumab (IVB), in preventing vitreo-retinal complications in patients of Eale’s Disease (ED).

Methods: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from May 2015 to December 2016. A total of 52 eyes of 26 patients, diagnosed with stage I or II of ED were randomly divided in two groups. Group A received monthly injections of IVB for 3 months, with steroids and laser photocoagulation. Group B received only steroids and laser treatment. Patients were followed for three months, and were analyzed for different clinical parameters.

Results: Mean age of study population was 28.5±2.64 years. Difference in frequency of patients requiring PPV and showing regression in neovascularization was statistically significant between both groups (p=0.005 for both). However, difference in frequency of patients showing progression in stage of ED, regression of vasculitis and best corrected visual acuity at 12 weeks  between two groups was not statistically significant (p= 0.012, 0.579, 0.046 respectively).

Conclusion: Intravitreal Bevacizumab injection, given monthly in patients of ED results in significantly more regression in neovascularization, and less requirement for PPV, as compared to those receiving standard steroids and laser photocoagulation treatment.


How to cite this:Mehboob MA, Tahir M, Batool H. Role of intravitreal bevacizumab in management of Eale’s Disease. Pak J Med Sci. 2018;34(2):-333-337.   doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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