Role of topical antibiotics in prophylaxis against endophthalmitis following intravitreal antibiotics

Abstract

Objective: To compare the prophylactic use of antibiotic with placebo to prevent post intra-vitreal endophthalmitis and other complications.

Methods: A prospective, cohort study was conducted at Ophthalmology Department, Fauji Foundation Hospital (FFH), from June 2016 to July 2017. A total of 1082 eyes of 673 patients were enrolled in this study. Patients were selected at non-random and divided into two groups. In Group-I, non – exposed, placebo eye drops were given after intravitreal bevacizumab injections and in Group-II, exposed, ofloxacin eye drops were given after intravitreal bevacizumab injections.

Results: Total 1082 eyes were given intravitreal bevacizumab injection in 673 patients. No patients in Group-I, non – exposed, receiving placebo eye drops developed post intra vitreal endophthalmitis, whereas only 01 (0.1%) patient developed post intravitreal endophthalmitis in Group-II, exposed, receiving ofloxacin eye drops. In inferential statistics the P-value was also statistically insignificant [x2 (1, N=1082) =0.95, P>0.05].

Conclusion: This study showed that topical antibiotic, as a prophylaxis after intravitreal injections has no role in the prevention of post intravitreal endophthalmitis and other complications.

doi: https://doi.org/10.12669/pjms.345.14817

How to cite this:Asghar A, Ellhai I, Obaid N, Sughra U. Role of topical antibiotics in prophylaxis against endophthalmitis following intravitreal antibiotics. Pak J Med Sci. 2018;34(5)1283-1287.   doi: https://doi.org/10.12669/pjms.345.14817

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