The role of complete blood inflammation markers in the prediction of spontaneous abortion | Bas | Pakistan Journal of Medical Sciences Old Website

The role of complete blood inflammation markers in the prediction of spontaneous abortion

Funda Yildirim Bas, Esra Nur Tola, Suheyla Sak, Basak Asli Cankaya


Objective: To investigate relationships between spontaneous abortion and complete blood count inflammation markers and their role in predicting spontaneous abortion.

Methods: This study was conducted at Department of Obstetrics and Gynecology between January 2012 and January 2017. A total of 570 participants, 325 diagnosed with spontaneous abortion and 245 control patients who underwent timely births were included into our study. The complete blood count inflammation markers included white blood cell (WBC), neutrophil (N), lymphocyte (L), neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV) and platelet-lymphocyte ratio level (PLR) were recorded.

Results: There was difference between the abortion groups and control groups in terms of complete blood count (CBC) inflammation markers, including WBC, PLT, neutrophil, lymphocyte, NLR, PLR, and MPV. We found decreased MPV, PLR levels and increased N, L and NLR in the first. and second. Abortion groups compared with the control group. WBC, N, L and NLR were positive predictive markers, and albeit with low sensitivity and specificity, MPV, PLR were found to be a negative predictive marker for the evaluation of spontaneous abortion.

Conclusions: Unlike several difficult and invasive tests, a CBC is a simple, inexpensive and easily available test. CBC inflammation markers, including WBC, N, L, NLR, PLR, and MPV, which were evaluated at the sixth gestational week, can be used for the risk assessment of spontaneous abortion in pregnancy.


How to cite this:Bas FY, Tola EN, Sak S, Cankaya BA. The role of complete blood inflammation markers in the prediction of spontaneous abortion. Pak J Med Sci. 2018;34(6):1381-1385.   doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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