The impact of Vitamin D replacement on Glucose Metabolism

Abstract

Objective: We investigated the impact of vitamin D supplementation on glucose metabolism in Vitamin D-deficient patients with prediabetes.

Methods: A total  of 66 subjects with the mean ages 52.2±9.9 years were included in this prospective and a 6-month follow-up study between 2008-2010. Vitamin D deficient patients ( < 25ng/ml) were supplemented with oral Vitamin D.

Results: Vitamin D deficiency ( < 25ng/ml) was found in 93.9% of the patients. Post replacement Vitamin D levels increased significantly and insulin, HbA1c, and HOMA-IR decreased significantly following Vitamin D replacement.

Conclusion: We found Vitamin D deficiency was very common in our study population. In Vitamin D deficient patients, supplementation treatment improved insulin resistance and glycemic parameters. Vitamin D replacement may be a promising intervention for the primary prevention of insulin resistance syndromes.

doi: http://dx.doi.org/10.12669/pjms.296.3891

How to cite this:Parildar H, Cigerli O, Unal DA, Gulmez O, Demirag NG. The impact of Vitamin D replacement on Glucose Metabolism. Pak J Med Sci 2013;29(6):1311-1314.   doi: http://dx.doi.org/10.12669/pjms.296.3891

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.