Clinical pathologies of breast cancer in the elderly and youths and their prognosis

Abstract

Objective: To explore the correlation between the clinical pathologies of breast cancer in the elderly and youths as well as their prognosis.

Methods: Two hundred and eighty breast cancer patients were divided into a youth group ( < 60, n=120) and an elderly group ( ≥ 60, n=160) according to the age. Their routine clinical pathological indices and immune indices were observed and determined, and the prognosis was observed after effective treatment.

Results: The positive expression rates of p63, CK5/6, CK14 and CK17 in the elderly group were significantly higher than those of the youth group (P < 0.05). The tumor-free survival rate of the youth group (95.8%) was significantly higher than that of the elderly group (84.4%) (P < 0.05). Multivariate Logistic regression analysis showed that the positive expressions of p63 and estrogen receptor, age, and postoperative chemotherapy were the independent risk factors of tumor-free survival rate (P < 0.05).

Conclusion: The immunohistochemical typing characteristics of the elderly and youths were different, and the prognosis of young patients was better, being correlated with the typing.

doi: http://dx.doi.org/10.12669/pjms.303.4929

How to cite this:Ji H, Ai N, Li Q, Zhang K, Di W. Clinical pathologies of breast cancer in the elderly and youths and their prognosis. Pak J Med Sci 2014;30(3):535-538.   doi: http://dx.doi.org/10.12669/pjms.303.4929

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