Effects of Ringerâ€™s sodium pyruvate solution on serum tumor necrosis factor-Î± and interleukin-6 upon septic shock
Objective: To study the effects of Ringerâ€™s sodium pyruvate solution on tumor necrosis factor-Î± (TNF-Î±) and interleukin-6 (IL-6) upon septic shock.
Methods: Ninety emergency patients with septic shock were divided into a treatment group and a control group by random draw. The control group was resuscitated with 50 ml of compound sodium chloride (Ringerâ€™s solution), and the treatment group was given 50 ml of Ringerâ€™s sodium pyruvate solution. Both groups were basically treated.
Results: All patients were successfully resuscitated. After treatment, extravascular lung water index, intrathoracic blood volume index, systemic vascular resistance index and cardiac index of the two groups were significantly improved compared with those before treatment (P<0.05). However, there were no significant inter-group differences at different time points (P>0.05). Blood lactic acid level, central venous oxygen saturation index and urine output were also improved after treatment, with significant inter-group differences (P<0.05). Serum TNF-Î± and IL-6 levels of both groups significantly decreased after treatment (P<0.05), and the levels of the treatment group were significantly lower than those of the control group (P<0.05). During 28 days of follow-up, the mortality rate of the treatment group (4.4%) was significantly lower than that of the control group (20.0%) (P<0.05).
Conclusion: Patients with septic shock are complicated with disordered expressions of inflammatory factors. During resuscitation, Ringerâ€™s sodium pyruvate solution can effectively promote blood circulation, mitigate inflammation and maintain acid-base equilibrium, thus decreasing the prognostic mortality rate.
The following manuscript has been retracted from May-June 2015 issue on the request of the authors who stated that â€œafter publication, their group found that it was difficult to repeat the results. We believe that there may be some flaws or operational loopholes, hence we would like to retract this paper. â€œ-Editor
Retraction in: Pak J Med Sci 2015;31(3):672-677. Â
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