Can living donor liver transplantation offer similar outcomesto deceased donor liver transplantation using expandedselection criteria for hepatocellular carcinoma?

Abstract

Objective: To compare the outcomes of living donor liver transplantation (LDLT) versus deceased donor liver transplantation (DDLT) for patients with hepatocellular carcinoma (HCC) in different selection criteria.

Methods: Data of patients with HCC who underwent liver transplantation between 2005 and 2013 at our center were reviewed. Clinical data of LDLT recipients and DDLT recipients were compared. The postoperative recurrence-free survival (RFS) rate and overall survival (OS) rate after LDLT versus DDLT were compared in the Milan recipients, the University of California, San Francisco (UCSF) recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients.

Results: Data of 255 patients were retrospectively reviewed in this study. Seventeen DDLT recipient and 9 LDLT recipients died during the perioperative period. Among the remaining 229 recipients (NLDLT=66, NDDLT=163), 96 patients met the Milan criteria, 123 recipients met the UCSF criteria, 135 patients met the up-to-seven criteria, 216 patients met the Hangzhou criteria, and 229 recipients met the Chengdu criteria. The overall RFS and OS rates of the Milan recipients, the UCSF recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients after LDLT and DDLT were all similar.

Conclusion: Using well-studied selection criteria, LDLT offers similar outcomes to DDLT for patient with HCC, even using expanded selection criteria.

Abbreviations: Alpha-fetoprotein (AFP), Deceased donor liver transplantation (DDLT), Hepatocellular carcinoma (HCC), Living donor liver transplantation (LDLT), Model for end-stage liver disease (MELD), Microvascular invasion (MVI), Recurrence-free survival (RFS) rate and overall survival (OS), University of California, San Francisco (UCSF).

doi: http://dx.doi.org/10.12669/pjms.314.7523

How to cite this:Chen LP, Li C, Wen TF, Yan LN, Li B, Yang JY. Can living donor liver transplantation offer similar outcomes to deceased donor liver transplantation using expanded selection criteria for hepatocellular carcinoma? Pak J Med Sci 2015;31(4):763-769.   doi: http://dx.doi.org/10.12669/pjms.314.7523

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