Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 24

April - June 2008 (Part-I)

Number  2


 

Abstract
PDF of this Article

Clinical spectrum of multiple sclerosis at a
Tertiary Care Hospital in Pakistan

Hoori Shahwar1, Syed Wasim Akhter2, Shaukat Ali3

ABSTRACT

Objective: To assess the clinical presentation of multiple sclerosis.

Methodology: This hospital based observational study was carried out from November 2004 to June 2005 at the Department of Neurology Jinnah Post Graduate Medical Center Karachi. Patients of multiple sclerosis (MS) diagnosed on Poserís criteria were observed on the basis of age at the onset, gender, family history, symptoms and signs, clinical course, magnetic resonance imaging, visual evoked potentials, cerebrospinal fluid and oligoclonal bands.

Results: Out of 20 patients there were 13 females with M:F ratio of 1:2. Mean age at presentation was 25.8 years. Family history was negative. Clinical presentation included pyramidal weakness (75%), visual defect (70%), sphincter disturbances (60%), sensory impairment (35%), cerebellar signs (30%) and paroxysmal spasm (25%). The clinical course of multiple sclerosis included Relapsing and Remitting RRMS (55%), Secondary Progressive SPMS (20%), Primary Progressive PPMS (15%) and Progressive Relapsing PRMS (10%). Optico-spinal type was seen in 55%. Magnetic resonance imaging of brain was positive in 75% and of cervico-dorsal in 100%. Visual evoked potential was abnormal in 85% and oligoclonal bands were present in 5%.

Conclusions: Multiple Sclerosis (MS) is not uncommon in Pakistan. The study revealed that young females were affected more compared with men with a ratio of 2:1 and mean age of onset was 25.8 years. Clinical type is in agreement with Asian variety of disease with high occurrence of optico-spinal presentation and low yield of oligoclonal band.

KEY WORDS: Multiple Sclerosis, Optico-Spinal MS, Oligoclonal Bands.

Pak J Med Sci    April - June 2008 (Part-I)    Vol. 24 No. 2    221-226


1. Hoori Shahwar,
Department of Neurology,
Jinnah Post graduate Medical Center Karachi.
2. Syed Wasim Akhter,
Department of Neurology,
Baqai Medical University Karachi. 
3. Shaukat Ali,
Department of Neurology,
Jinnah Postgraduate Medical Center Karachi.
Baqai Medical University Karachi,
Karachi - Pakistan.

Correspondence: 

Dr. Hoori Shahwar,
Department of Neurology,
Jinnah Postgraduate Medical Center,
Karachi, Pakistan
E-Mail: drhoori@gmail.com 

* Received for Publication: September 26, 2007
* Revision Received: January 24, 2008
* 2nd Revision Received: February 8, 2008
* Final Revision Accepted: February 10, 2008


INTRODUCTION

Multiple Sclerosis (MS) is an acute immune-mediated inflammatory disease that causes focal demyelination of the central nervous system (brain and spinal cord); it also causes axonal loss. There is evidence for limited remyelination of indeterminate significance.1,2 The disease is characterized by dissemination in space and time i.e. the lesions involve separate parts of the central nervous system and occurs at different times. It usually begins in early adult life and pursues a variable course, causing significant morbidity.2 The variation in prevalence according to geographical location and modification of clinical picture by ethnic factors are all well known features of the disease.3 MS is more prevalent in Caucasians and has been extensively studied and reported from the West.4 There have been a few studies reported from Asia, particularly from south Asia.5-7 Optic nerve and spinal cord involvement, with predominant visual impairment in the beginning of the course are more common in the Asian variety.8 The aim of present study was to assess the clinical pattern and course of MS at a tertiary care center in Pakistan.

METHODOLOGY

The study was conducted at Jinnah postgraduate medical centre, Karachi, one of the largest tertiary care hospitals in Pakistan. A total of twenty patients with MS fulfilling Poserís criteria9 were studied from November 2004 till June 2005. The parameters for clinical presentation included: age at the onset, gender, family history, pyramidal weakness, visual defect, sphincter disturbances, sensory impairment, cerebellar signs and paroxysmal spasm. The clinical course included: Relapsing remitting, secondary progressive, primary progressive and progressive relapsing MS. Topography of MS comprises of: spinal only, optico-spinal, optico-cranial, optco-spino-cranial, optico-spino-cerebellar, spino-cerebellar and cerebellar-only. Opticospinal MS, which is one of the presentations of MS, was considered when bilateral visual impairment and transverse myelitis developed concomitantly or within several weeks of each other, with or without subsequent improvement.8,10Patients were also classified into the following categories based on Poserís criteria as: Clinically definite, lab supported definite, clinically probable, lab supported probable MS. Investigations including blood tests, MRI studies, VEP test and CSF analysis were carried out in all patients to substantiate the diagnosis of MS and to exclude other diseases, particularly connective tissue disorders. Blood tests comprised of complete blood counts, ESR, biochemistry and, where required, antinuclear antibodies, double strength DNA and rheumatoid factor. CSF analysis was done for oligoclonal bands. VEP was performed for the evidence of central demyelination. MRI was performed to show multiple white matter lesions in the brain or intramedullary plaques in the spinal cord.

RESULTS

The total number of patients studied was twenty. The females were 13 with male to female ratio of 1:2. The mean age of presentation was 25.8 years; in males it was 27.8 years and in females 25 years. According to Poserís criteria out of 20 cases 13(65%) were CDMS, while 7(35%) were CPMS.

As far as the clinical course of MS is concerned, out of 20 patients eleven (55%) followed the RRMS, four (20%) had SPMS, three (15%) were in PPMS and only two (10%) were in PRMS. The most common presentation of MS with motor weakness and pyramidal tract involvement was noted in 75%, followed by visual impairment in 70%, sphincter disturbance in 60%, sensory disturbances 35%, cerebellar involvement in 30% and paroxysmal spasm in 25% of the cases. (Table-I)

As regards topography 55% of our patients have optico-spinal form, in which 20% were fulfilling the criteria of pure optic spinal MS, or Neuromyelitis optica, and 35% have had optico-spinal MS, with positive brain MRI., as well as 15% was optico-spino-cerebellar, and only 10% had cereballar only. (Table-II) CSF examination was normal in 19/20 patients thus it was positive for oligoclonal band in 5% only. VEP was performed in all cases and it was abnormal and keeping with a demyelinating disorder in 17(85%) of the cases.

All 20 cases underwent brain MRI in which 15(75%) had the findings compatible with MS. We have done cervico-dorsal MRI in 12 cases, which showed demyelination in all cases. Brain and spinal both MRI was done in 12 cases, in which four cases (20%) had normal scan of Brain with plaques in spinal MRI involving more than three segments of vertebra. (Table-III).

DISCUSSION

Multiple Sclerosis is less common in tropical countries. Three neuroepidemiological studies from different parts of south Asia did not document any case of multiple sclerosis.11 Iran and Srilanka are considered to b area of low prevalence of MS,5,7 Although several reports are available from India.12,13,14 As per our knowledge so far there is no in depth study available from Pakistan regarding prevalence of MS or its clinical spectrum.15

In our study, the mean age of presentation was 25.8 years. In males it was 27.8 years while in female it was 25 years which is similar as reported by Singhal and Wadia14 and Bhatia et al,16 which was also 26 years. Instead of that in one of brazilian series17 the mean age of presentation was higher as compare to our study, in which the mean age of presentation was 32 years. This might be related to a longer interval of time between onset of disease and clinical diagnosis. The youngest case reported in the present study was 17 years and oldest was 40 years old.14,15,18,19

The female to male ratio was 2:1 in our study as well as in five studies from different parts of Asia which showed male preponderance (range 1.25-2) and one study   has shown female predominance. Kurtzke et al have, however, shown female predominance (female: male-1.8: 1) among US veterans.20 In Brazilian series, there is also predominance of female.17, 21

In our study the relapsing-remitting form (RR) (65%) is the most common form, followed by secondary progressive form (35%) which is same as reported by Singhal and Wadia,14 and Bhatia et al.,16 compared to that in brazilian series in which RRMS is 91%, followed by PPMS is 8% and only 1% is SPMS.17, 22 An increased frequency of visual involvement is a common feature in Asian variety.23-25 In our study pyramidal involvement is the most common presentation (75%) followed by optic involvement (70%), sensory disturbances in 35% and cerebellar involvement (30%) of the cases. This feature correlates well with the earlier observation from south Asia23 and Japan.25

OSMS is a unique demyelinating disease characterized by recurrent optic neuritis and myelitis, and rare or minor involvement of the brain24,26 relatively higher female/male ratio, a lower frequency of CSFOB. 27 In our study there were four (20%) of cases which have pure OSMS with normal brain MRI with male predominance as male: female ratio was 3:1, oligoclonal band were negative in all four cases spinal cord lesions extending over three vertebral segments on spinal cord MRI, with gadolinium enhancement. However 10 cases (8.5%) of pure OSMS were reported in Japanese series28,29 of 118 cases of multiple sclerosis, with definite female preponderance and negative CSFOB.

Many investigators in Western countries have reported that relapsing OSMS is a type or variant of multiple sclerosis,30,31 and that OSMS phenotype may occur in classical multiple sclerosis in which demyelinating lesions are disseminated throughout the CNS. In our study 7(35%) of optico-spinal cases had recurrent optic neuritis and transverse myelitis with positive brain MRI.

Papaiz-Alvarenga et al27 who had the series with the largest proportion of African Brazilian (31.8%) patients reported 5.6% with OSMS clinical form, Leite et al,32 had 15.6%, whereas Lana - Peixoto,21 with 24% of African Brazilian patients, reported, a prevalence of 12% with OSMS and suggested that his patients presented a clinical form more alike the Asian MS patients.

Major difference in Caucasians and South Asian series has been the incidence of cerebellar involvement, which was found in over 80% in the former and33 30-58% in the later.24  This is corroborated in our study also in which only 30% of patients had cerebellar involvement.

MRI has now become one of the key investigations in the diagnosis of multiple sclerosis. It is reported to be positive in a varying percentage of cases in different studies, the figures ranging from 50% to 95%.34,35

In our study, the Brain MRI showed lesions consistent with MS in 75% of cases, as well as the spinal MRI has shown 100% accuracy. The true accuracy of MR imaging remains difficult to determine but the overall yield is reported to be 80%.35,36 The high sensitivity of MRI is offset by its lack of specificity, though certain characteristics may strongly favor MS, none of them are diagnostic by themselves.

CSFOB represent abnormal synthesis of gamma globulins in the Cerebral Spinal Fluid and therefore strongly implicate an immuno-pathological process.37,38 It has been found that in Caucasians the CSFOB are found in a higher number of cases (90%) and tend to remain stable during the course of disease whereas in Asian studies39 its incidence has been found to be ranging between 33 to 45%.40,41 In our study positivity of oligoclonal band is only 5%. Evoked potentials are useful to identify clinically silent lesions in the visual pathways the incidence of abnormalities on VEPs in various studies42,43 ra- nge from 75-97%. In our study abnormalities in VEPís were also found in 85% of pat ients.

During comparison with other studies the prevalence of MS in Brazil27,32 is estimated at the mean age of 32 and its occurrence in females is eight fold to males, substantially lower than in Western countries. However, the proportion of patients with RRMS in this population is reported to be higher than in Western populations.

In our Study we found that MS in Asian countries has several patterns that distinguish MS in Pakistan from MS in Western countries.33 Occurrence of disease in female patients is quite high as compared to male the ratio in West is 1:15 whereas in Pakistan it is 1:2 as shown in Table-IV. Moreover the number of cases of RRMS were observed quite low as compared to other areas. Only 55% patients were reported to have RRMS as compared to 91% in Brazil and 89% in South Asia. Clinical features of MS in our study indicate that occurrence of cerebral cases was lower as compared to other regions.

CONCLUSIONS

We can conclude that MS is not uncommon in Pakistan. The mean age at onset was slightly lower compared to the other series, and there was a greater preponderance of women, as has been seen the world over. The clinical pattern is more similar to the Asian series than the western series. The incidence of OSMS was found to be higher than that reported in Japanese, South Asian and Brazilian series. The CSFOB are less seen than other Asian and western studies.  

ACKNOWLEDGMENT

This study was supported by Multiple Sclerosis Research and Welfare Trust, Pakistan. These findings were presented in preliminary form at The First International Congress of Emirates Neurology Society (EMINS) and the 5th GCC Neurology Symposium, March 2006, UAE.

REFERENCES

1. Compston A, Coles A. Multiple Sclerosis.Lancet 2002;359:1221-31.

2. Weinshenke BG. Natural History of Multiple sclerosis. Ann Neurol 1994;36(suppl):S6-11.

3. Alaev BA. Ethnic factors and their relation to the pathogenesis and geography of multiple sclerosis. Zh Nevropatol Psikhiatr Im S S Korsakova 1992;92:9-12.

4. Murray S, Bashir K, Penrice G, Womersley SJ. Epidemiology of multiple sclerosis in Glasgow. Scott Med J 2004;49:100-04.

5. Kalanie H, Gharagozli K, Kalanie AR. Multiple sclerosis: report on 200 cases from Iran. Mult Scler 2003;9:36-8.

6. Gangopadhyay G, Das SK, Sarda P, Saha SP, Gangopadhyay PK, Roy TN, et al. Clinical profile of multiple sclerosis in Bengal. Neurol India 1999;47:18-21.

7. Senanayake B, Ranawaka U, Wijesekara J. Multiple sclerosis in Sri Lanka. Ceylon Med J 2001;46:159-60.

8. Weinshenker BG, Fujihara K, Pittock SJ. The Asian optico-spinal form of MS is the same entity as Neuromyelitis optica in Causcasians: Insights from a novel serum marker. Neurology 2004;62(suppl 5): A 480.Abstract P06.061.

9. Poser CM, Paty DW, Scheinberg L. New diagnosis criteria for multiple sclerosis: guidance for research protocol. Ann Neurol 1983;30:389-99.

10. Lana-Peixoto M, Lana-Peixoto MIV. Is multiple sclerosis in Brazil and Asia alike? Arch Neuropsychiatry 1992;50:119-25

11. Gourie DM, Rao VN, Prakashi R. Neuroepide-miological study in semi urban and rural areas in South India: pattern of neurological disorders including motor neurone disease In: Motor neurone Disease. M Gourie Devi (Ed.) Oxford and IBH publishing Co, New Delhi 1987;10-12.

12. Mathew NT, Mathai KV, Abraham J. Incidence and pattern of demylinating disease in India. J Neurol Sci 1971;13:27-38.

13. Verma NP, Ahuja JK. Spectrum of multiple sclerosis in Delhi region. J Assoc Physicians India 1982;30:421-2.

14. Singhal BS, Wadia NH. Profile of patients of multiple sclerosis in Bombay region. J Neurol Sci 1975;26:259-70.

15. Raza SQ, Anjum MN, Bakhtiari M, Rasool F. Multiple Sclerosis in a Tropical Population Pak J Neurol 1998;4(1):16-24.

16. Vasconcelos CCF, Miranda-Santos CM, Alvarenga RMP. Clinical Course of Progressive Multiple Sclerosis in Brazilian Patients. Neuroepidemiology 2006;26:233-9.

17. Mathew NT, Mathai KV, Abraham J. Incidence and pattern of demylinating disease in India. J Neurol Sci 1971;13:27-38.

18. Verma NP, Ahuja JK. Spectrum of multiple sclerosis in Delhi region. J Assoc physicians India 1982;30:421-2.

19. Kurtzke JF, Beebe GW, Norman JE Jr. Epidemiology of multiple sclerosis in U.S. veterans: 1. Race, sex and geographic distribution. Neurology. 1979;29:1228-35.

20. Lana-Peixoto M, Lana-Peixoto MIV. Is multiple sclerosis in Brazil and Asia alike? Arq Neuropsiquiatr 1992,50:119-25.

21. Callegaro D, Godbaum M, Morais L, Tilbery CP, Moreira MA, Gabbai AA, et al. The prevalence of multiple sclerosis in the city of Sao Paulo, Brazil. Acta Neurol Scand 2001;104:2208-2137.

22. Kalanie H, Gharagozli K, Kalanie AR. Multiple sclerosis: report on 200 cases from Iran, Multiple Sclerosis 2003;9(1):36-8 SAGE Publications.

23. Kuroiwa Y, Shibashaki H, Tabira T. Clinical picture of multiple sclerosis in Asia. In: Multiple sclerosis - East and West, Kuroiwa Y, Kurland LT (Eds). Kyushu University Press Fukuoka, Japan 1982;43-7.

24. Shibashaki H, Kuroda Y, Kuroiwa Y. Clinical studies of multiple sclerosis in Japan: Classical multiple sclerosis and Devicís disease. J Neurol Sci 1974;23:215-22.

25. Wingerchuk DM, Hogancamp WF, OíBrien PC, Weinshenker BG. The clinical course of neuromyelitis optica .Neurology 1999;53:1107-14.

26. Papais-Alvarenga RM, Miranda-Santos CM, Puccioni-Sohler M, de Almeida AM, Oliveria S, Basilio De, et al. Optic neuromyelitis syndrome in Brazelian patients. J Neurol Neurosurg Psychiatry 2002;73:429-35.

27. Misu T, Fujihara K, Nakashima I, Miyazawa I, Okita N, Takase S, et al. Pure optico-spinal form of multiple sclerosis in Japan. Brain 2002;125:2460-8.

28. Kira J. Multiple sclerosis in the Japanese population. Lancet Neurol 2003;2:117.

29. OíRiordan JI, Gallagher HL, Thompson AJ, Howard RS, Kingsley DP, Thompson EJ, et al. Clinical, CSF, and MRI findings in Devicís neuromyelitis optica. J Neurol Neurosurg Psychiatry 1996;60:382-7.

30. OíRiordan JI, Thompson AJ, Kingsley DP, MacManus DG, Kendall BE, Rudge P, et al. The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up. Brain 1998;121:495-503.

31. Leite ACCB, Andrade C, Novis S. Epidemiology of 118 cases of multiple sclerosis after 15 years of follow-up on the reference center of Hospital da RestauraÁ„o, Recife, Pernambuco, Brazil, Arch Neurol Psychiatric 1990;48(Supl):66A

32. Kira J, Kanai T, Nishimura Y, Yamasaki K, Matsushita S, Kawano Y, et al. Western versus Asian type of multiple sclerosis, immunogenetically and clinically distinct disorders. Ann Neurol 1996; 40:569-74.

33. Paty DW, McFarlin DE, Mc Donald WI. Magnetic resonance imaging and laboratory aids in the diagnosis of multiple sclerosis. Ann Neurol 1988;29:48:19-46.

34. Ormerod IEC, Miller DH, Mc Donald WI. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurologic lesions. Brain 1987;110:1579-1616.

35. Chong HT, Ramli N, Lee KH, Singhal BS, Chong J, Tan CT, et al. Magnetic Resonance Imaging of Asians with Multiple Sclerosis was Similar to that of the West, The Canadian J Neuro Sci 2006;33(1).

36. Walsh MJ, Tourtellottee WW. The cerebrospinal fluid in multiple sclerosis. In Pathology, Diagnosis and Management. Hallpike JP, Adams CWM and Tourtellottee WW (Eds.) Chappman and Hall, London, 1983;275-358.

37. Vladimir V, Markelov, Maxim V. Trushin Multiple sclerosis and neurochemical disturbances Pak J Med Sci 2007;23(1):145-9.

38. Siddiqui I, Aleem S, Kayani N, Baig S. CSF oligoclonal bands in multiple sclerosis J Pak Med Assoc 2002;52(8):351-3.

39. Andersson M, Alvarez-Cermeno J, Bernardi G, Cogato I, Fredman P, Frederiksen J, et al. Cerebrospinal fluid in the diagnosis of multiple sclerosis, a consensus report. J Neurol Neurosurg Psychiatry 1994;57:897-902.

40. Tramo MJ, Schenk MJ, Lee BCP. Evoked potentials and MRI in the diagnosis of multiple sclerosis. Neurology 1985;355:105.


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