Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 23

January - March 2007

Number 1


 

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Relationship of zinc concentrations in blood and seminal
plasma with various semen parameters in infertile subjects

Hasan Ali1, Masood Ahmed2, Mukhtiar Baig3, Moazzam Ali4

ABSTRACT

Objective: To find out relationship of zinc concentrations in blood and seminal plasma with various semen parameters between fertile and infertile men.

Design: Prospective study.

Setting: This study was carried out in the Infertility Clinic of Jinnah Postgraduate Medical Center (JPMC), Karachi and Department of Biochemistry, Basic Medical Sciences Institute, JPMC, Karachi.

Subjects & Methods: Fifty eight primary infertile male subjects, without any treatment, who had regular unprotected intercourse for at least 12 months without conception with their partners, aged 20-40 years, were selected from Infertility Clinic Jinnah Postgraduate Medical Center, Karachi. After semen analyses they were grouped as, oligospermic (30), and azoospermic (28). Twenty five known fertile male selected from general population and after semen analysis were taken as normospermic control group. Semen analyzed according to WHO criteria. Serum and seminal plasma zinc were estimated by 5Br. PAPS Colorimetric method.

Results: This study showed significant difference in serum and seminal zinc levels in normospermic, oligospermic (p<0.05) and azoospermic (p<0.005) subjects. Seminal plasma zinc showed a positive correlation with sperm count and negative with sperm motility in normospermic and oligospermic and negative correlation with volume, pH, WBC concentration in all three groups. There was no correlation found with sperm morphology.

Conclusion: On the basis of the findings of this study and those of other reports, zinc may contribute to fertility through its significant effects on various semen parameters. It seems that the estimation of seminal plasma zinc may help in investigation and treatment of infertile males.

KEY WORDS: Seminal Zinc, Oligospermic, Azoospermic, Infertility.

Pak J Med Sci January - March 2007 Vol. 23 No.1  111-114


1. Dr. Hasan Ali MBBS, M. Phil,
Assistant Professor,
Department of Biochemistry,
2. Dr. Masood Ahmed MBBS, M. Phil,
Professor,
Department of Anatomy,
1-2: Baqai Medical University, Karachi.
3. Dr. Mukhtiar Baig MBBS, M.Phil
Associate Professor, Department of Biochemistry,
Liaquat National Medical College, Karachi.
4. Dr Moazzam Ali MBBS, M.Phil
Professor, Department of Anatomy,
Ziauddin Medical University, Karachi.

Correspondence:
Dr. Hasan Ali,
16-B, 5th Floor, Society Apartment,
Kashmir Road,
Karachi Pakistan.

* Received for Publication: September 20, 2005
* Revision Received: March 26, 2006
* Revision Accepted: July 19, 2006



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