Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

-

ORIGINAL ARTICLE

-

Volume 23

January - March 2007

Number 1


 

Full Text
PDF of this Article

Evaluation of carcinoemberionic antigen CEA and CA15.3
tumor markers in patients operated for breast cancer

Mohammad Hossein Sarmast Shooshtary1, AH Talaizadeh2, S Assar3,
B Khalaj Arnineh4, J Nateghi5, M Rahdar6

ABSTRACT

Introduction: Tumor markers are biochemical signs of tumor existence and consist of cell surface antibodies, cytoplasm proteins, enzymes and hormones.

Patients and Method: We evaluated the variability of tumor marker levels in following-up patients without the evidence of the disease after the resection of a primary breast cancer. Carcinoemberionic antigen (CEA) and CA 15.3 were measured by commercially available methods in serial blood samples collected from 94 patients referred to surgical and oncological center of Ahwaz.

Results: In 72 cases with normal CA 15. 3, metastasis and recurrence occurred for 12% and 4.17 respectively. In 12 cases with abnormal CA15.3 metastasis and recurrence occurred for 54.55% and 4.55% respectively. In 80 cases with normal CEA metastasis and recurrence occurred for 15% and 5% respectively, and in 14 cases with abnormal CEA metastasis and recurrence occurred for 64.24% and 14% respectively.

Conclusion: The incidence of metastasis is high in patients with abnormal tumor markers, and CA15.3 is more sensitive in following-up and evaluating the patient’s response to the treatment.

KEYWORDS: Tumor marker, Breast cancer, Follow-up, Recurrence, Metastasis.

Pak J Med Sci January - March 2007 Vol. 23 No.1  115-118


1. Dr. Mohammad Hossein Sarmast Shooshtary
2. Dr. AH Talaizadeh
General Surgeon,
Department of Surgery,
Imam Khomeini Hospital
3. Dr. S. Assar
4. Dr. B Khalaj Arnineh
General Practitioner
5. Dr. J Nateghi
Hematologist Oncologist,
Department of Haematology Oncology,
Shafa Hospital
6. Dr. M Rahdar
Department of Mycoparasitology

1-6: School of Medicine,
Jundi-Shapour University of Medical Sciences,
Ahwaz – Iran.

Correspondences:
Dr. Mohammad Hossein Sarmast Shoushtary,
General Surgery Ward,
Imam Khomeini Hospital,
Azadegan Street,
Ahwaz – Iran.
E-Mail: sarmastm@hotmail.com

* Received for Publication: February 4, 2006
* Accepted: June 14, 2006



HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

Professional Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@pjms.com.pk