Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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CASE REPORT

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Volume 24

January - March 2008

Number  1


 

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A rare case of hypomelanosis of ITO

Sh.Shaafi1, H. Herizchi2

ABSTRACT

Hypomelanosis of Ito (HI) is a syndrome with hypopigmented whorls of skin along the Blascho lines. The old name, Incontinentia pigmentosa achromiance was probably used because HI appears to be the negative image of incontinentia pigmentosa. This disorder is inherited as an autosomal dominant trait with variable penetrance and the implicated genes are 9q33 and q11-13, Xp11. Chromosomal mosaiscm is believed to be the reason that hypomelanosis of Ito is so varied in phenotype. Hypopigmented skin lesions appear as whorls or streaks on any part of body and tend to progress onto uninvolved areas. The cutaneous lesion is often associated with developmental and neurological abnormalities. Pyramidal tract dysfunction, mental retardation and seizures are common neurological signs. Ophtalmologic disorders are also present.

KEYWORDS: Incontinentia pigmentosa achromians, Diagnostic criteria, Hypomelanosis Ito.

Pak J Med Sci    January - March 2008    Vol. 24 No. 1    173-174


1. Sh. Shaafi MD,
Assistant Professor of Neurology,
Department of Neurology, Razi Hospital,
2. H. Herizchi MD,
Assistant professor of Dermatology,
Department of Dermatology, Sina Hospital,
1-2: Tabriz University of Medical Science,
Tabriz Iran.

Correspondence
Dr. Sh. Shaafi
E-mail: ShaafiS@tbzmed.ac.ir

* Received for Publication: July 26, 2007
* Revision Received: October 2, 2007
* 2nd Revision Received: October 20, 2007
* Final Revision Accepted: October 26, 2007



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