Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 24

January - March 2008

Number  1


 

Abstract
PDF of this Article

Inevitable peripartum hysterectomy in
a tropical hospital: Indications and
maternofetal outcome

Adesiyun Adebiyi Gbadebo1, Eseiegbe Edwin2, Ameh Charles Anawo3

ABSTRACT

Objectives: To determine the indications for inevitable peripartum hysterectomy (IPH), associated demographic variables and the materno fetal outcome.

Methodology: A retrospective analysis of twenty two patients that had inevitable peripartum hysterectomy (IPH) during the study period of 4 years, July 2001 to June 2005.

Results: The mean age of the patients was 32.4 years with a range of 18 to 47 years. The parity ranged from 1 to 9. The parity distribution was positively skewed indicating the rate of IPH increased with parity. Sixteen (72.7%) patients did not have antenatal care and 21(%) out of the 22 patients were refereed from other health facilities. Indications for IPH were ruptured uterus in 16(72.7%) patients, uterine atony in 4(18.2%) patients. Of the 22 patients, 15 (68.2%) delivered per abdomen while 7(31.8%) delivered per vagina. The indications for abdominal delivery were laparotomy for ruptured uterus with extraction of the fetus in 11 (50%) patients and caesarean section in 4(18.2%) patients on account of placenta praevia in 2 patients. Of the 7 patients that delivered per vaginam, 3(13.6%) had spontaneous vertex delivery, 1(4.5%) had vacuum delivery, 2(9.1%) had breech extraction of second twin and 1(4.5%) patient had embryotomy. Subtotal hysterectomy was the most commonly preformed type of hysterectomy in 17(77.5%) of the cases. High maternal mortality of 59.1% and perinatal mortality of 77.3% was recorded in the study.

Conclusion: Ruptured uterus which is associated with poor pre-surgical clinical state was the leading indication for IPH in this study. This may be responsible for the high maternal and fetal mortality recorded in this study and not necessarily the hysterectomy procedure itself.

KEY WORDS: Peripartum, Hysterectomy.

Pak J Med Sci    January - March 2008    Vol. 24 No. 1    122-126


1. Adesiyun Adebiyi Gbadebo (FWACS),
Department of Obstetrics & Gynaecology,
2. Eseiegbe Edwin (FWACPaed),
Department of Paediatrics,
3. Ameh Charles Anawo (FWACS, DRH),
Department of Obstetrics & Gynaecology,
1-3: Ahmadu Bello University Teaching Hospital,
Shika Zaria,
Kaduna State,
Nigeria.

Correspondence

Dr. Adebiyi G. Adesiyun,
P.O.Box 204,
Kaduna - Kaduna State,
Nigeria.
Email: adebiyi_g@yahoo.com

* Received for Publication: September 6, 2007

* Accepted: November 30, 2007


INTRODUCTION

In Nigeria and some other black African countries, hysterectomy is not a widely accepted operation due to the persistent cultural bias to accept absence of the uterus and subsequent family limitations with amenorrhea. The obstetrician will only resort to hysterectomy in the peripartum period where it becomes inevitable.

In most developing countries, the maternal and child health care delivery system are poorly developed. Health data indicating the quality of maternal and child health in Nigeria, confirmed high figures. Contributing to this high figures are poverty and poor infrastructural facilities in a nation with a fast growing population without the appropriate means and effective strategy to cope with the situation.

Inevitable peripartum hysterectomy (IPH) is an emergency live saving operation that is mostly performed in cases of intractable obstetric hemorrhage.1 In Nigeria, obstetric hemorrhage is amongst the three leading causes of maternal mortality and morbidity like other developing countries.2 Ruptured uterus, is a cause of obstetric hemorrhage and one of the dreaded complications of pregnancy to which a woman maybe subjected to,3 ruptured uterus was the leading indication of IPH in the developed world before 1980,4 and it was associated with high fetal mortality.5 However, recent studies emanating from developed countries, found placenta accereta as the most common indication for emergency peripartum hysterectomy (EPH).4 This is due to the increasing caesarean section rate and the more successful conservative treatment of uterine atony. Against this background, we evaluated the indications for IPH and the maternofetal outcome in a tropical hospital.

PATIENTS AND METHODS

During the period between July 2001 and June 2005 twenty two cases of IPH were done in the obstetric unit of the Ahmadu Bello University Teaching Hospital, Kaduna. Their case files were retrieved and their medical records reviewed. The study was a retrospective analysis of twenty two patients that had IPH, which was defined as emergency hysterectomy performed in the third trimester of pregnancy, during labour and after delivery because of obstetric haemorrhage.

The time interval between diagnosis and surgical intervention was determined by the speed and effectiveness of resuscitation, availability of funds for treatment, availability of operating space in the operating theatre, availability of blood for transfusion and the efficiency of call network for the medical team. A good number of the unbooked patients were caught up in one or more of these problems resulting in delay in operative intervention. For the purpose of this review, unbooked patient are those patient that did not register and attend our antenatal clinic.

RESULTS

The records of 22 patients that had IPH was analysed. The mean age was 32.4 years with a range of 18 to 47 years, and the parity ranged from para one to para nine. The parity distribution was positively skewed, indicating the rate of IPH increased with parity. A significant percentage (72.2%) of the patients were un-booked for antenatal care; they were referred. Using the last menstrual period or previous sonogram, 68.2% of the pregnancies were term. The gestational age ranged from 35 to 42 weeks.

Of the 22 patients, 68.2% had no previous scar, 27.2% had previous caesarean section scar and 9.1% had previous myomectomy. Rupture of the pregnant uterus was the leading indication for IPH in this study, with a percentage of 72.7%. This was distantly followed by uterine atony (13.6%) and placenta praevia accerta in 4.5% of cases.

Mode of delivery shows that 11(50%) patients had abdominal delivery of partially or completely extruded from the ruptured uterus, 4(18.2%) patients had caesarean section and 3 (13.6%) patients had spontaneous vaginal delivery. Other mode of deliveries recorded were vacuum delivery (4.5%) breech extraction (9.1%0 and embryotomy in 1 4.5%) patients. The indications for the caesarean section were placenta praevia in two cases, fetal distress, one case and two previous caesarean section in one patient.

Overall, 15(68.2%) patients had hysterectomy done following abdominal delivery of fetuses while 7(31.8) hysterectomies followed vaginal deliveries. Subtotal hysterectomy was the commonly performed type of hysterectomy, done in 77.3% of cases. In this review, the maternal mortality was 59.1%, all due to complications arising from severe haemorrhage. The leading causes of maternal morbidity including in patients that later died, were haemorrhage / anemia, puerperal pyrexia and wound disruption. Perinatal mortality of 77.3% was recorded, perinatal morbidity were mainly sepsis, anemia, asphyxia and jaundice.

DISCUSSION

Hysterectomy in the peripartum period is a rare, but life saving emergency operation that is associated with both intra and post operative complications. In our society where the emphasis is towards a large family and menstrual function is of paramount importance, peripartum hysterectomy is not done to unless it becomes inevitable. The incidence of IPH in this review is 1.83/1000 births, this is in line with reported incidence from the United States which ranged from 1.2 to 2.7 per 1000 births,7,8 but on the contrary, our incidence is high compared to figures emanating from some European countries. The incidence in Ireland9 and Norway10 are 0.3/1000 births and 0.2/1000 births respectively. The wide disparity in the incidence of IPH between the United States and some European countries may be explained by the high caesarean section rate in the United States which predisposes to placenta praevia and placenta increta, which are now the leading indications for IPH in the developed countries.4,6,7 This disparity can be further substantiated by similarity in the incidences of IPH following vaginal delivery in the European and United States studies.4,6,8

In this study, the incidence of IPH following caesarean section was 0.5/1000 births, this is low compared with 1.6/1000 births reported in the Netherlands.1 However, we found our incidence of 0.41/1000 births for IPH after vaginal delivery to be high compared with figures between 0.1/1000 births and 0.3/1000 births quoted for the United States and some European countries.4,6,8 These findings can be best explained by the intense aversion among many in Africa to surgical deliveries11 and the preference to try vaginal delivery especially in our society where desire and emphasis is to have many children.12 This has led to our low caesarean section rate with consequential high morbidity and mortality following vaginal births due to poorly developed emergency obstetric care service in a society where majority of the pregnant women are not supervised in pregnancy, labour and delivery.

Interestingly, in the developed countries, placenta accereta is the most common indication for IPH,13,14 while ruptured uterus which was one of the two leading indication for IPH up till the 1980s in the developed countries, is the leading indication of IPH in our review. In most of the patients, the uterus ruptures before the patients arrives in the hospital15 and they present in a moribond state with the fetus already partially or completely extruded into the peritoneal cavity. The situation is usually made worse due to lack of promptness in resuscitative and definitive management as a result of financial constraints and availability of blood for transfusion.

Subtotal hysterectomy was the commonly performed surgery in this review, as was in other studies.3,16 In patients that had rupture of gravid uterus which was the commonest indication in this review, subtotal hysterectomy is said to be a safer procedure and may be quicker.3 It is associated with less post operative morbidity since the infected and torn uterus is removed. 3,16

Though IPH is associated with high maternal mortality and morbidity, maternal mortality of 59.1% recorded in this study as against 4% reported in a similar study by Anneka Kwee,1 may not be directly linked to the surgery itself but rather to the bad presurgical clinical state of these patients with ruptured uterus at presentation. Ghatak3 in his review of 163 cases of ruptured uterus in Northern Nigeria recorded an over all maternal mortality of 46.5%, which is similar to the figure recorded in this study where uterine rupture was the dominant indication for IPH.

The perinatal death of 77.3% recorded in this review is high compared to 6.3% reported in a study in the Netherlands.1 This can be attributed to ruptured uterus being the commonest reason for IPH and delay in seeking and getting medical intervention at the three levels. In various studies of ruptured uterus which was the main indication for peripartum hysterectomy in this study, Ghatak3 and Groene17 reported high perinatal mortality of 93% and 100% respectively, while Makinde, et al18 reported low survival rate of 17.6%, which are all comparable to figures in this study.

It is note worthy from this study that the maternal and perinatal mortality following IPH is greatly influenced by the leading indication for IPH which is ruptured uterus and not the surgery itself. This may explain the wide disparity in the figures from developed countries and our study.

Ruptured uterus is a significant contributor to maternal mortality in Nigeria, with percentage contribution ranging from 28.2% to 31.9% in studies.19,20 In order to decrease the incidence of IPH and reduce maternal mortality, conscious effort should be targeted towards the prevention and prompt management of cases of ruptured uterus. This can be achieved by provision and improvement in maternal care service, availability of blood transfusion services and accessibility to health care facilities via provision of good roads, transportation, communication services and alleviation of poverty and eradication of illiteracy. However, these can only be a reality if the issue is given due recognition and it is backed up by appropriate political will to re-order priorities in resource allocation without resulting to expensive measures or complex technology.

REFERENCES

1. Anneke KML, Bots GH, Visser A, Hein WB. Emeregncy peripartum hysterectomy: A prospective study in the Netherlands. Eur J Obst Gyne Reprod Bio 2006;124(2):187-92.

2. Ochejele S, Adama O, Dasy PH. Contribution of direct obstetric complications to maternal deaths in Makurdi, North Central Nigeria. Trop J Obstet Gynaecol 2005;22(1):37-8.

3. Ghatak DP. Rupture of the uterus: A review of 146 cases. Trop J Obst Gynae 1990;8:41-4.

4. Zorlu CG, Turan C, Isik AZ, Danlsman N, Mungan T, Gokmen O. Emergency hysterectomy in modern obstetric practice. Acta Obstet Gynaecol Scand 1998;77:186-90.

5. Menon MKJ. Rupture uterus. Obstet Gynaecol BritCmwlth 1962;75:1296-1300.

6. Baskshi S, Meyer BA. Indication for and outcomes of emergency peripartum hysterectomy. J Reprod Med 2000;44:733-7.

7. Kastner ES, Figueroa R, Garry D, Naulik D. Emeregncy peripartum hysterectomy: Experience at a community teaching hospital. Obstet Gynecol 2002;99:971-5.

8. Stance LM, Schrimmer DB, Paul RH, Mishell DR. Emergency peripartum hysterectomy and associated risk factors. Am J Obstet Gynecol 1993;168:879-83.

9. Langdana M, Geary W, Haw D, Keane F. Peripartum hysterectomy in the 1990s: Any new leson? J Obtet Gynaecol 2001;21:121-3.

10. Engelsen IB, Albrechtsen S, Iversen OF. Peripartum hysterectomy incidence and maternal morbidity. Acta Obstet Gyneol Scand 2001;80:409-12.

11. Mock CN, Viser L, Elkine TE, Wilson JB. Vaginal delivery after previous caesarean section in a rural West African Hospital. Int J Gynecol Obstet 1991;35:187-93.

12. Okpere EE, Oronsaye AU, Imoedemhe DA. Pregnency and delivery after caesarean section A review of 494 cases. Trop J Osbt Gynecol 1980;3(2):45-8.

13. Read JA, Cotton DB, Millar FC. Placenta accerta: changing clinical aspect and outcome. Obstet Gynecol 1980;56:31-4.

14. Sturdee DW, Rushton DI. Caesarean section and postpartum hysterectomy. Br J Obstet Gyanecol 1986;93:270-4.

15. Egwuatu VE. Rupture of the gravid uterus: An extra-abdominal presentation. Nig Med J 1980;10(5&6):234-46.

16. Megafu U. Factors influencing maternal survival in ruptured uterus. Int J Gynacol Obstet 1985;23:475-80.

17. Groene GP. Uterine rupture: review of 144 cases. Obstet Gynecol 1974;44:682-7.

18. Makinde OO, Akinyemi SA. Review of ruptured uterus. Trop J Obst Gynae 1990;8(N2):52-4.

19. Ugochukwu OJ, Ejikeme UBN, Egwuatu VE. Contribution of ruptured uterus to maternal mortality in rural south eastern Nigeria. Trop J Obstet Gynaecol 2005;22(2):184-8.

20. Ochejele S, Adama O, Daru PH. Contribution of direct obstetric complications to maternal death in Markurdi, north central Nigeria. Trop J Obstet Gyaecol 2005;22(1):37-8.


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