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Volume 26 |
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Number 1 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ORIGINAL ARTICLE |
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Volume 26 |
January - March 2010 |
Number 1 |
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Differentiation of Keratoacanthoma from Squamous
Cell Carcinoma by Argyrophilic Nucleolar
Organizer Region (AgNOR) StainingFariba Abbasi1, Zahra Yekta2, Shirin Lotfinegad3, Golnaz Khurani4
ABSTRACT
Objectives: The objective was to evaluate the differentiation of keratoacanthoma from squamous cell carcinoma by using argyrophilic nucleolar organizer region staining.
Methodology: Thirty one cases of keratoacanthoma and 31 cases of squamous cell carcinoma (S.C.C) were selected. The AgNOR staining carried out. Counting of AgNOR was done in 100 cells of each tumor. Two criterias including M.AgNOR (mean number of AgNORs) and P.AgNOR (percentage of nuclei with five or more than five AgNORs per nucleous) were used. Statistical analysis was done by Mann- Whitney test.
Results: Significant increase in M.AgNOR and P.AgNOR was found in S.C.C compared with keratoacanthoma ( M.AgNOR =16.52 ± 10.1 and P.AgNOR = 84.12 ± 23.4 in S.C.C compared with M.AgNOR = 6.58 ± 4.4 and P.AgNOR = 52.29 ± 26.7 in keratoacanthoma, P=0.000). Exceptionally overlapping was seen.
Conclusion: This study indicated that the AgNOR counting is a valuable diagnostic criterion for differentiation of keratoacanthoma and S.C.C especially in cases with borderline histologic features.
KEY WORDS:
Keratoacanthoma, Squamous Cell Carcinoma, AgNOR.Pak J Med Sci January - March 2010 Vol. 26 No. 1 123-125
How to cite this article:
Abbasi F, Yekta Z, Lotfinegad S, Khurani G. Differentiation of Keratoacanthoma from Squamous Cell Carcinoma by Argyrophilic Nucleolar Organizer Region (AgNOR) Staining. Pak J Med Sci 2010;26(1):123-125
1. Fariba Abbasi, MD,
Assistant Professor of Pathology,
2. Zahra Yekta, MD,
Associate Professor of Community Medicine,
3. Shirin Lotfinegad, MD,
Associate Professor of Pathology,
4. Golnaz Khurani, MD,
Pathologist,
1-4. Department of Pathology, Faculty of Medicine,
Urmia University of Medical Sciences, Urmia, Iran
Correspondence:
Fariba Abbasi, MD,
Assistant Professor of Pathology,
Department of Pathology, Imam Khomeini Hospital,
Urmia University of Medical Sciences, Urmia, Iran
Email: faribaak2002@yahoo.com
* Received for Publication: May 26, 2009
* Revision Received: December 15, 2009
* Revision Accepted: December 17, 2009
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