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Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
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Evaluation of 278 HLA-B27 positive patients
suspected of Seronegative Spondyloarthropathies
S. Jalal Emam1, Shide Badri2, Ahmad Bayat3, Nasireh Dashtebozorg4, Azar Khosravi5
ABSTRACT
Objective: To determine HLA-B27 prevalence in patients suspected of Seronegative spondyloarthropathy referred to the Transplantation Department of Blood Transfusion Organization, and to evaluate clinical findings among HLA-B27 positive patients.
Methodology: One thousand six hundred ten patients having clinical manifestation of seronegative SpAs were screened for HLA typing by serological methods from January 1997 to June 2002 at Transplantation Department of Blood Transfusion Organization, Ahwaz, Iran. Serologic-based HLA typing using Antigen-specific sera to determine a person’s HLA type was performed. Among these patients, individuals found HLA-B27 positive were investigated regarding clinical findings, age, and sex distribution.
Results: In this study the frequency of HLA-B27 antigen was 17.26% (278 cases). The minimum age in males was 10 years and the maximum age in female was 70 years. Median age with seronegative SpAs findings (34.2% including 28.42% females, 71.57% males) was 20-30 years. Based on our results, the most frequent clinical manifestation, was peripheral joints arthritis (58.7%; 34.35% females, 65.65 % males). There were no association between any of the major clinical manifestations and age or sex distribution.
Conclusions: These findings confirm the strong association of the HLA B27 allele with various types of spondyloarthritis and suggests that HLA typing would help in the diagnosis of seronagative SpAs, specially ankylosing spondylitis with indeterminate clinical presentation and also in identifying at risk family members.
KEY WORDS: Seronegative, Spondyloarthropathies (SNSA), HLA-B27 antigen.
Pak J Med Sci October - December 2007 (Part-I) Vol. 23 No. 5 728-732
1. Dr. S. Jalal Emam, Ph.D
2. Dr. Shide Badri, MD
3. Dr. Ahmad Bayat, MD
4. Dr. Nasireh Dashtebozorg, BSc.
1-4: Transplantation Department,
Blood Transfusion Organization, Khuzestan – Iran.
5. Dr. Azar Khosravi
Dept. of Microbiology, School of Medicine &
Infectious and Tropical Diseases Research Center,
Ahwaz Judi Shapur University of Medical Sciences,
Ahwaz, Iran.
Correspondence
Dr. S. Jalal Emam,
Dept. of Laboratory Medicine, Paramedical School,
Ahwaz Jondishapour University of Medical Sciences,
Ahwaz – Iran.
E-mail: j_emam@yahoo.com
* Received for Publication: February 14, 2007
* Revision Received June 23, 2007
* Revision Accepted July 3, 2007
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