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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
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Pre-eclampsia and lipid profile
Rubina Aziz1, Tabassum Mahboob2
ABSTRACT
Objectives: The present study was designed to evaluate the role of lipid profile alteration in the development of Pre-eclampsia.
Methodology: We selected 32 pregnant women, 16 healthy pregnant women (mean age 25.56±3.68) as normal and 16 already diagnosed preeclamptic women (mean age 24.65±4.25) as study group. Serum lipid profile (total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL- cholesterol) of thirty two women with Pre-eclampsia (n=16), normotensive women (n=16) were monitored.
Results: The serum triglyceride concentrations increased significantly (232.18±106.41 vs. 113.12 ±21.3, P<0.01) while Serum HDL-cholesterol concentrations decreased significantly (39.75±11.99 vs. 51.18±06.09, P<0.01) in preeclamptic group as compared to normal pregnant women.
Conclusion: Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia.
KEY WORDS: Preeclampsia, High Density Lipoproteins, Triglycerides, Low Density Lipoproteins.
Pak J Med Sci October - December 2007 (Part-I) Vol. 23 No. 5 751-754
1. Rubina Aziz
Department of Biochemistry,
Federal Govt Urdu University for Arts,
Sciences and Technology,
Karachi – Pakistan.
2. Tabassum Mahboob
Department of Biochemistry,
University of Karachi, Karachi – Pakistan.
Correspondence:
Rubina Aziz
E-mail: rubinaaziz67@hotmail.com
* Received for Publication: December 23, 2006
* Revision Received: April 11, 2007
* Revision Accepted: August 12, 2007
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