Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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Volume 23

October - December 2007 (Part-I)

Number  5


 

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Pre-eclampsia and lipid profile

Rubina Aziz1, Tabassum Mahboob2

ABSTRACT

Objectives: The present study was designed to evaluate the role of lipid profile alteration in the development of Pre-eclampsia.

Methodology: We selected 32 pregnant women, 16 healthy pregnant women (mean age 25.56±3.68) as normal and 16 already diagnosed preeclamptic women (mean age 24.65±4.25) as study group. Serum lipid profile (total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL- cholesterol) of thirty two women with Pre-eclampsia (n=16), normotensive women (n=16) were monitored.

Results: The serum triglyceride concentrations increased significantly (232.18±106.41 vs. 113.12 ±21.3, P<0.01) while Serum HDL-cholesterol concentrations decreased significantly (39.75±11.99 vs. 51.18±06.09, P<0.01) in preeclamptic group as compared to normal pregnant women.

Conclusion: Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia.

KEY WORDS: Preeclampsia, High Density Lipoproteins, Triglycerides, Low Density Lipoproteins.

Pak J Med Sci    October - December 2007 (Part-I)    Vol. 23 No. 5    751-754


1. Rubina Aziz
Department of Biochemistry,
Federal Govt Urdu University for Arts,
Sciences and Technology,
Karachi – Pakistan.
2. Tabassum Mahboob
Department of Biochemistry,
University of Karachi, Karachi – Pakistan.

Correspondence:

Rubina Aziz
E-mail: rubinaaziz67@hotmail.com

* Received for Publication: December 23, 2006
* Revision Received: April 11, 2007
* Revision Accepted: August 12, 2007



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