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Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
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Magnesium sulphate as a safe treatment for
persistent pulmonary hypertension of newborn
resistant to mechanical hyperventilation
Masoud Dehdashtian1, Kemaladin Tebatebae2
ABSTRACT
Objective: To see the effects of magnesium sulphate in newborn with persistent pulmonary hypertension of newborn (PPHN) who did not respond to mechanical hyperventilation and are candidate for Extra Corporeal Membrane Oxygenation (ECMO).
Methodology: Ten newborn who were admitted to Neonatal Intensive Care Unit (NICU) with profound hypoxia and respiratory failure due to PPHN were treated with conventional mechanical ventilation and then mechanical hyperventilation. The newborns who did not respond to mechanical Hyperventilation were treated with magnesium sulphate infusion.
Results: Nine out of ten babies survived and one of them died. The differences between the mean AaDo2, OI index, and PH after mechanical hyperventilation and magnesium sulphate administration was significant.
Conclusions: Magnesium has a role in the treatment of PPHN patients who do not respond to hyperventilation or may be applied instead of hyperventilation.
KEY WORDS: Persistent pulmonary hypertension newborn, Magnesium sulphate, Mechanical hyperventilation, Oxygen index, Alveolar-arterial oxygen differences.
Pak J Med Sci October - December 2007 (Part-I) Vol. 23 No. 5 693-697
1. Masoud
Dehdashtian, Neonatologist,
2. Kemaladin Tebatebae, Anesthesiologist,
1-2: Neonatal Intensive Care Unit,
Imam Khomini Hospital, Faculty of Medicine,
Ahwaz Jondi shapour of Medical Science,
Ahwaz – Iran.
Correspondence
Masoud Dehdashtian
Neonatal Ward, Imam Khomini Hospital,
Azadegan Street, Ahwaz – Iran.
E mail: Dehdashtian@ajums.ac.ir
* Received for Publication: January 4, 2007
* Revision accepted: July 13, 2007
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