Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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CASE REPORT

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Volume 26

October - December 2010

Number  4


 

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EBV-induced fulminant hepatic failure
treated with liver transplantation

Ibrahim Silfeler1, Hilal Kurnaz2, Yesim Acar3,
Bayram Ali Dorum4, Vefik Arica5, Fugen Pekun6

ABSTRACT

Viral hepatitis is the leading cause of fulminant hepatitis. Infectious mononucleosis caused by primary infection of EBV is a self-limiting lymphoproliferative disease, and shows concomitant clinical features such as pyrexia, cervical lymphadenopathy, liver dysfunction and hepatosplenomegaly. Even though approximately more than 90 percent of all humans are infected with EBV it rarely causes hepatitis and even if it does it is usually benign and it rarely causes hepatic failure in which the outcome has a high mortality rate. We report a case of fulminant hepatic failure in an immunocompetent 3.5 years old girl caused by primary EBV infection that was treated by orthotropic liver transplantation. This observation emphasizes that EBV must be known as a possible cause of fulminant hepatitis and that liver transplantation is probably the unique therapeutic option to avoid a usually fatal course.

KEY WORDS: Transplantation, EBV, Hepatitis.

Pak J Med Sci    October - December 2010    Vol. 26 No. 4    971-972

How to cite this article:

Silfeler I, Kurnaz H, Acar Y, Dorum BA, Arica V, Pekun F. EBV-induced fulminant hepatic failure treated with liver transplantation. Pak J Med Sci 2010;26(4):971-972


1. Ibrahim Silfeler
2. Hilal Kurnaz
3. Yesim Acar
4. Bayram Ali Dorum
5. Vefik Arica,
Department of Paediatrics,
Mustafa Kemal University, Hatay, Turkey
6. Fugen Pekun
1-4, 6: Okmeydani Training and Research Hospital,
Istanbul, Turkey.

Correspondence:

Ibrahim Silfeler,
Alaattin koyu, Gungor uydukent 30 parsel D11/3,
Antakya, Hatay,
TURKEY.
E-mail: drsilfeler@gmail.com

* Received for Publication: August 14, 2010

* Accepted: August 25, 2010



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