Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 26

October - December 2010

Number  4


 

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In vitro antifungal activity of Satureja
Khuzestanica
Jamzad against
Cryptococcus neoformans

Majid Zarrin1, Nasrin Amirrajab2, Batool Sadeghi-Nejad3

ABSTRACT

Objective: Finding the antifungal activity of Satureja Khuzestanica Jamzad extract against Cryptococcus neoformans isolates.

Methodology: The dilution in agar method was used to test the plant extracts against C. neoformans. The minimum inhibitory concentration (MIC) was described as the lowest concentration capable to inhibit any visible fungal growth. All nine C. neoformans strains used in this study were environmental isolates.

Results: The MIC value of Satureja Khuzestanica against C. neoformans isolates observed in this study demonstrated that the extract of this plant have antifungal activity. The MIC of extract of Satureja Khuzestanica ranged from 62.5-2000 g/ml-1. The extract of this plant at concentration of 500 g/ml-1 inhibited 78% of C. neoformans isolates.

Conclusion: This study demonstrated that the extract of Satureja Khuzestanica has anticrptococcal activity. Our work open viewpoints of find more efficient medicines of herbal origin in the treatment of fungal mycoses.

KEY WORDS: Antifungal activity, Satureja Khuzestanica, Crptococcus neoformans.

Pak J Med Sci    October - December 2010    Vol. 26 No. 4    880-882

How to cite this article:

Zarrin M, Amirrajab N, Nejad BS. In vitro antifungal activity of Satureja Khuzestanica Jamzad against Cryptococcus neoformans. Pak J Med Sci 2010;26(4):880-882


1. Majid Zarrin,
Dept. of Parasitology & Mycology, Medical School,
2. Nasrin Amirrajab,
Dept. of Laboratory Sciences, Paramedical School,
3. Batool Sadeghi-Nejad,
Dept. of Parasitology & Mycology, Medical School,
1-3: Ahvaz Jundishapur University of Medical Sciences,
Ahvaz, Iran.

Correspondence:

Dr. Majid Zarrin,
Department of Medical Parasitology & Mycology,
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
E-mail: mjzarrin@yahoo.co.uk

* Received for Publication: March 12, 2010

* Accepted: June 25, 2010



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