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Volume 25 |
October - December 2009 (Part-II) |
Number 6 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 25 |
October - December 2009 (Part-II) |
Number 6 |
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Sex hormones and erectile dysfunction
in hemodialysis patients
Muhammad Anees1, Asim Mumtaz2,
Muhammad Haris Barki3,
Muhammad Ibrahim4,Shabir Hussain5, Muhammad Uzair6
ABSTRACT
Objective: To determine the prevalence of Erectile Dysfunction (ED) in hemodialysis patients (HD) and to study the associated changes in sex hormones in these patients.
Methodology: This is a hospital based cross sectional study conducted at hemodialysis units of Shalamar and Mayo Hospitals, Lahore from January to March 2008. All male patients with ESRD on maintenance (HD), whose spouses were alive and able to perform intercourse, were included in the study. Patients with cognitive and communication deficits were excluded from study. International index of erectile function-5(IIEF-5), adopted in Urdu was used for determination of prevalence of ED. Demographic data was collected and sex hormones {total testosterone, Dihydroepiandrosteronediones (DHEA), Follicle Stimulating Hormone (FSH), Leutinizing Hormone (LH) and serum Prolactin} were measured.
Results: A total number of fifty patients were included in the study. The major cause of ESRD was diabetes mellitus 28 (56%). The prevalence of ED was 86% with a mean IIEF-5 score 10.36 + 7.13. The majority of patients, 33 (66%), were suffering from a severe degree of ED. The total testosterone level was low in 30 (60%) patients and DHEA were low normal in most of patients, 46 (92%). Compared to patients with non-ED, those with ED had a significantly lower DHEA (1.93 ± 0.73 vs 0.81 ± 0.11, p value = 0.007). Total testosterone and DHEA had a negative correlation with age and diabetes mellitus. FSH showed a variable response in these patients, it was low (< 1.55 mIU/ml) in three, normal (1.55 + 9.74 mIU/ml) in 39 and high (> 9.74 mIU/ml) in eight patients. LH was low (< 1.2 mIU/ml) in two, normal (1.2 + 7.8 mIU/ml) in thirty three and high (> 7.8 mIU/ml) in fifteen patients. FSH and LH showed a positive correlation with duration of dialysis. Prolactin level was low in 21(42%) patients. Total testosterone, FSH, LH and Prolactin had no association with ED.
Conclusion: The majority of the patients suffering from ESRD, on maintenance HD had ED. DHEA was significantly lower in patients with ED, compared to those with no-ED. Total testosterone and DHEA had an inverse relationship with diabetes and age of the patients. Total testosterone, FSH, LH and prolactin did not affect erectile function.
KEY WORDS:
Haemodialysis, erectile dysfunction, DHEA.FSH, LH, Prolactin, IIEF-5.Pak J Med Sci October - December 2009 (Part-II) Vol. 25 No. 6 922-927
How to cite this article:
Anees M, Mumtaz A, Barki MH, Ibrahim M, Hussain S, Uzair M. Sex hormones and erectile dysfunction in hemodialysis patients. Pak J Med Sci 2009;25(6):922-927.
1. Dr. Muhammad Anees, MBBS,
FCPS,
Assistant Professor of Nephrology,
King Edward Medical University, Lahore
2. Dr. Asim Mumtaz, MBBS, MPhil,
Associate Professor of Chemical Pathology,
University of Health Sciences, Lahore.
3. Dr. Muhammad Haris Barki, MBBS, PhD,
Director Sexual Health Institute of Pakistan, Lahore.
4. Muhammad Ibrahim,
Assistant Professor of Statistics,
Govt.Diyal Singh College, Lahore.
5. Shabir Hussain, Msc Lab Technology,
University of Health Sciences, Lahore.
6. Muhammad Uzair, MBBS,
House Officer, Urology Department,
Mayo Hospital,
Lahore - Pakistan.
Correspondence:
Dr. Muhamamd Anees
726-L Block, Johar Town
Lahore - Pakistan.
E-Mail: dranees109@hotmail.com
* Received for Publication: February 14, 2009
* Revision Received: October 19, 2009
* Accepted: October 20, 2009
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