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Volume 24 |
October - December 2008 (Part-I) |
Number 5 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 24 |
October - December 2008 (Part-I) |
Number 5 |
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Hypotonia in infants and young children:
An etiological analysisAmirsalari S1, Kavehmanesh Z2, Khalili Matinzadeh Z3, Afsharpayman S4,
Torkaman M5, Javadipour M6, Kakoie Shourkaie J7, Ghazavi Y8ABSTRACT
Objective: To determine the relative frequency of specific disorders that present with hypotonia in Iran.
Methodology: It is a retrospective, cross–sectional study in which 107 children with hypotonia, aged one month to three years, were evaluated in Baqyiatallah Hospital between June 2003 and June 2006. Children were categorized into groups of central and peripheral hypotonia, and specific diagnosis of each of the two groups was made by clinical findings, neuro imaging, metabolic and genetic tests, muscular enzymes, EMG-NCV (Electromyography-Nerve conduction velocity) and thyroid function tests.
Results: Of the 107 infants, one hundred one (94.4%) children had central hypotonia, four (3.7%) had peripheral hypotonia and in two (1.9%) the hypotonia had other causes. The most common cause of central hypotonia was idiopathic central hypotonia thirty four (31.8%), followed by cerebral palsy in twenty two (20.6%), brain structural abnormality in nineteen (17.8%), inborn errors of metabolism fourteen (13.1%), genetic disorders seven (6.5%) and the TORCH(Toxoplasma, Rubella, Cytomegalovirus, Herpes simplex) syndrome three (2.9%).
Conclusion: In our study "central hypotonia" was most prevalent etiology of hypotonia. The most common cause of central hypotonia was idiopathic central hypotonia followed by cerebral palsy, brain structural abnormality, inborn errors of metabolism, genetic disorders and the TORCH syndrome.
KEYWORDS: Hypotonia, Central hypotonia, Peripheral hypotonia.
Pak J Med Sci October - December 2008 (Part-I) Vol. 24 No. 5 744-747
How to cite this article:
Amirsalari S, Kavehmanesh Z, Khalili Matinzadeh Z, Afsharpayman S, Torkaman M, Javadipour M, et al. Hypotonia in infants and young children: An etiological analysis. Pak J Med Sci 2008;24(5):744-47.
1. Amirsalari S, MD,
Assistant Professor,
2. Kavehmanesh Z, MD,
Associate Professor,
Department of Pediatrics,
Faculty of Medicine,
3. Khalili Matinzadeh Z, MD,
4. Afsharpayman S, MD,
5. Torkaman M, MD,
3-5: Assistant Professor,
Department of Pediatrics,
Faculty of Medicine,
6. Javadipour M, MD,
7. Kakoie Shourkaie J, MD,
General Physician,
8. Ghazavi Y,
Student
1-8: Baqyiatallah University of Medical Sciences,
Tehran – Iran.Correspondence
Susan Amirsalari,
Child Neurologist, Dept. of Pediatrics,
Faculty of Medicine,
Baqyiatallah University of Medical Sciences,
Molla-Sadra St,
Tehran, Iran.
E Mail: susanamirsalari@yahoo.com
* Received for Publication: February 11, 2008
* Accepted: July 26, 2008
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